Spreading Depressions and Periinfarct Spreading Depolarizations in the Context of Cortical Plasticity
نویسندگان
چکیده
منابع مشابه
Spreading Depression, Spreading Depolarizations, and the Cerebral Vasculature.
Spreading depression (SD) is a transient wave of near-complete neuronal and glial depolarization associated with massive transmembrane ionic and water shifts. It is evolutionarily conserved in the central nervous systems of a wide variety of species from locust to human. The depolarization spreads slowly at a rate of only millimeters per minute by way of grey matter contiguity, irrespective of ...
متن کاملAge-related impairment of metabovascular coupling during cortical spreading depolarizations.
30 Cortical spreading depolarizations (SDs) may lead to long-lasting alterations in 31 cerebral blood flow (CBF), which contribute to neuronal dysfunction and hypoxic tissue 32 injury. There is growing evidence to suggest that age-related structural and functional 33 alterations of the neurovascular unit significantly increase both the incidence of SDs and 34 aggravate their functional conseque...
متن کاملP 23: Apoptosis Following Cortical Spreading Depression in Juvenile Rats
Introduction: Repetitive cortical spreading depression (CSD) can lead to cell death in immature brain tissue. Caspases are involved in neuronal cell death in several CSD-related neurological disorders. Yet, whether repetitive CSD itself can induce caspase activation in adult or juvenile tissue remains unknown. Inducing repetitive CSD in somatosensory cortices of juvenile and adult rats in vivo,...
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Migraine is a disorder that afflicts nearly one tenth of the population. Involving both nervous and vascular system, it has been found as a prominent factor of disability. The migraine attacks may be initiated in the brainstem or may begin peripherally in the meninges while the role of cortical activation preceding an attack is also debated. Although available treatments, more studies on migrai...
متن کاملSpreading and synchronous depressions of cortical activity in acutely injured human brain.
BACKGROUND AND PURPOSE Cortical spreading depression (CSD) has been much studied experimentally but never demonstrated unequivocally in human neocortex by direct electrophysiological recording. A similar phenomenon, peri-infarct depolarization, occurs in experimental models of stroke and causes the infarct to enlarge. Our current understanding of the mechanisms of deterioration in the days afte...
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ژورنال
عنوان ژورنال: Neuroscience
سال: 2021
ISSN: 0306-4522
DOI: 10.1016/j.neuroscience.2020.10.032